Book a little boat at Cernobbio's port and enjoy the lake from the water. You can book it for 3 hours for approx 100 Euro and it will be sufficient to take a quick tour of the west coast all along Cernobbio, Moltrasio (the most beautiful village on that side and perhaps of the whole lake), Carate Urio and Laglio, where Clooney lives. If you prefer a guided tour, ask the concierge at Villa D'Este in Cernobbio, the most beautiful hotel in the World according to several rankings and the unforgettable location of the World's most important Concorso d'Eleganza for classic cars (apologies, Pebble Beach). After the tour, treat yourself with an aperitivo or a dinner at the hotel, or a full day ticket at the SPA of the hotel. Just note that rates are in line with the standards of the hotel: fair enough.
Discover your on-the-road side through a drive from Como on the "west Coast" of the lake, again across Cernobbio, Moltrasio, Carate, Laglio, up to Brienno and beyond, until you reach Villa Carlotta in Tremezzo: this amazing Villa hosts one of the biggest botanic garden in Europe, right above the lake. The only replica in existence of the worldwide famous Canova's "amore e psiche" statue is visible in the main hall. On your way up alongside the lake, remember to stick to the old road "Strada Regina Vecchia", a way more romantic than the faster highway uphill, the "Strada Regina Nuova".
But, if you are fed up with the grandiose athmosphere of 5-stars hotel, I recommend you spend at least a night at the B&B Gardenia, a glamorous villa located 8-km inland from Como downtown, just recently turned into a guesthouse with spectacular good taste.
Back in Como for a breakfast the day after, don't miss, for any reasons, to stop by at pasticceria Monello in via Manzoni, owned and operated by real Sicilians for crazily good pastries and cannoli.